【Research Review】Latest Report on Carbohydrate Loading Ratios and Gastrointestinal Tolerance in Long-Distance Endurance Running: Exploring the Relationship Between Clinical Medicine and Athletic Performance (Article 1246)

Reference Journal Source: International Journal of Sport Nutrition and Exercise Metabolism • International Scientific Research Findings Review Series

This article explores the balancing strategy between carbohydrate loading ratios and gastrointestinal tolerance in long-distance endurance runners.

Physiological Basis of Carbohydrate Loading

Muscle and liver glycogen stores are limited, and prolonged endurance exercise (typically exceeding 90 minutes) can easily lead to “hitting the wall” due to glycogen depletion. Carbohydrate loading strategies aim to maximize muscle and liver glycogen stores—and delay the onset of hitting the wall—by increasing carbohydrate intake ratios (while maintaining or reducing training volume) in the days before competition.

Glucose-to-Fructose Ratios for In-Race Fueling

When using glucose-based carbohydrates alone, the absorption rate of the intestinal glucose transporter (SGLT1) has a physiological ceiling (approximately 60 grams per hour); exceeding this amount can easily cause gastrointestinal discomfort. Research has found that pairing fructose (absorbed via a different transporter, GLUT5) can increase the total amount of carbohydrate absorbed. This is also the physiological basis for the growing popularity of “dual/multiple carbohydrate source” sports nutrition products (glucose + fructose combinations)—the common ratio falls around 2:1 (glucose:fructose), which can raise the hourly carbohydrate intake ceiling to approximately 90 grams.

Comparison of Gastrointestinal Discomfort Incidence Across Different Fueling Strategies (Illustrative)

Core Scientific Conclusions and Practical Recommendations

• Pre-race loading timeline: It is recommended to gradually increase carbohydrate intake (to over 70% of total calories) 2–3 days before the race while significantly reducing training volume, allowing sufficient time for glycogen storage
• Gut training: Gradually increasing in-race carbohydrate intake and frequency during long-term training allows the gut to adapt to high-volume carbohydrate absorption loads, significantly reducing the risk of gastrointestinal discomfort during the actual race
• Regularize fueling timing: Rather than waiting for thirst or hunger, it is recommended to fuel little and often at fixed intervals (e.g., every 20–30 minutes) to maintain stable blood glucose levels
• Individualized testing: Osmolality and taste tolerance vary from person to person across different products; before major races, be sure to test your fueling strategy during training or simulation races to avoid trying new products for the first time on race day

Common Research Q&A (FAQ)

Q: Will carbohydrate loading make you gain fat or weight?

A: The weight gain from short-term loading is mainly water (glycogen storage simultaneously retains water), which naturally subsides after the race as glycogen is depleted. It is not fat accumulation, so there is no need for excessive concern.

Q: Is it necessary to use glucose-fructose blended products for in-race fueling?

A: Not necessary, but for longer events (e.g., marathons over 4 hours) requiring higher carbohydrate intake, blended sources can indeed help raise the absorption ceiling and reduce gastrointestinal burden.

References and Academic Citations

1. International Journal of Sport Nutrition and Exercise Metabolism — Research directions related to absorption rates of multiple-carbohydrate-source sports nutrition.
2. Sports Medicine — Literature related to gut training and gastrointestinal tolerance in endurance sports.

Related Topic Reading

• 【Research Review】Latest Report on Carbohydrate Loading Ratios and Gastrointestinal Tolerance in Long-Distance Endurance Running: Exploring the Relationship Between Clinical Medicine and Athletic Performance (Article 958)
• 【Research Review】Latest Report on Carbohydrate Loading Ratios and Gastrointestinal Tolerance in Long-Distance Endurance Running: Exploring the Relationship Between Clinical Medicine and Athletic Performance (Article 1273)
• 【Research Review】Latest Report on Carbohydrate Loading Ratios and Gastrointestinal Tolerance in Long-Distance Endurance Running: Exploring the Relationship Between Clinical Medicine and Athletic Performance (Article 1339)
• 【Research Review】Latest Report on Carbohydrate Loading Ratios and Gastrointestinal Tolerance in Long-Distance Endurance Running: Exploring the Relationship Between Clinical Medicine and Athletic Performance (Article 313)